Drugs to be avoided in LQTS patients
Database search: last updated on June 26, 2025.
Drug Name:
Drug Class:
Therapeutic Use:
Risk Category:
Antiarrhythmic
Drugs |
|---|
Amiodarone |
Disopyramide |
Dofetilide |
Dronedarone |
Flecainide |
Hydroquinidine |
Nifekalant |
Procainamide |
Quinidine |
Sotalol |
Drugs |
|---|
Pilsicainide |
Vernakalant |
AntiBiotics
Drugs |
|---|
Azithromycin |
Ciprofloxacin |
Clarithromycin |
Erythromycin |
Gatifloxacin |
Grepafloxacin |
Levofloxacin |
Moxifloxacin |
Roxithromycin |
Sparfloxacin |
Drugs |
|---|
Bedaquiline |
Delamanid |
Gemifloxacin |
Lefamulin |
Norfloxacin |
Ofloxacin |
Sitafloxacin |
Telavancin |
Telithromycin |
Drugs |
|---|
Clofazimine |
Garenoxacin |
Metronidazole |
Piperacillin/ Tazobactam |
AntipsyChotics
Drugs |
|---|
Chloropromazine |
Chloroprothixene |
Droperidol |
Haloperidol |
Levomepromazine |
Levosulpiride |
Mesoridazine |
Pimozide |
Sertindole |
Sulpiride |
Sultopride |
Thioridazine |
Drugs |
|---|
Aripiprazole |
Asenapine |
Clotiapine |
Clozapine |
Cyamemazine (Cyamepromazine) |
Flupentixol |
Iloperidone |
Lumateperone |
Lurasidone |
Melperone |
Paliperidone |
Perphenazine |
Pimavanserin |
Pipamperone |
Promethazine |
Prothipendyl |
Zotepine |
Zuclopenthixol |
Drugs |
|---|
Amisulpride |
Olanzapine |
Quetiapine |
Risperidone |
Ziprasidone |
Antidepressants
Drugs |
|---|
Citalopram |
Escitalopram |
Drugs |
|---|
Aripiprazole |
Desipramine |
Gepirone |
Imatinib |
Imipramine (Melipramine) |
Maprotiline |
Mianserine |
Moclobemide |
Nortriptyline |
Opipramol |
Tacrolimus |
Trimipramine |
Venlafaxine |
Antiemetics
Drugs |
|---|
Chloropromazine |
Domperidone |
Droperidol |
Ondansetron |
Drugs |
|---|
Dolasetron |
Granisetron |
Palonosetron |
Promethazine |
Tropisetron |
Anesthetic agents
Drugs |
|---|
Cocaine |
Propofol |
Sevoflurane |
Drugs |
|---|
Isoflurane |
Antiviral drugs
Drugs |
|---|
Efavirenz |
Lopinavir/Ritonavir |
Remdesivir |
Rilpivirine |
Saquinavir/Ritonavir |
Drugs |
|---|
Amantadine |
Atazanavir |
Nelfinavir |
Telaprevir |
Anti-Cancers
Drugs |
|---|
Aclarubicin |
Arsenic trioxide |
Osimertinib |
Oxaliplatin |
Vandetanib |
Drugs |
|---|
Bendamustine |
Bosutinub |
Cabozatinib |
Capecitabine |
Ceritinib |
Cobimetinib |
Crizotinib |
Dabrafenib |
Dasatinib |
Entrectinib |
Epirubicin |
Eribulin mesylate |
Fluorouracil (5-FU) |
Glasdegib |
Inotuzumab ozogamicin |
Lapatinib |
Lenvatinib |
Midostaurin |
Necitumumab |
Nilotinib |
Pazopanib |
Revomenib |
Ribociclib |
Sorafenib |
Sunitinib |
Tamoxifen |
Tazemetostat |
Tipiracil/ Trifluridine |
Vemurafenib |
Antianginal drugs
Drugs |
|---|
Ivarbradine |
Bepridil |
Drugs |
|---|
Ranolazine |
Diuretics
Drugs |
|---|
Torsemide (Torasemide) |
Metolazone |
Indapamide |
Hydrochlorothiazide |
Furosemide |
Bendrofulumethiazide (Bendrofluazide) |
Known Risk of TdP
This medication prolongs the QT interval and carries a known risk of Torsades de Pointes, even when taken as directed.
Possible Risk of TdP
This drug can cause QT prolongation; however, there is currently a lack of evidence to suggest a risk of TdP when taken as recommended.
Conditional Risk of TdP
This drug is linked to Torsades de Pointes (TdP), but only under specific circumstances. These include excessive dosing, use in patients with certain conditions like hypokalemia, or when taken alongside interacting medications. Additionally, TdP can occur if factors facilitate or induce it, such as inhibiting the metabolism of another QT-prolonging drug or causing electrolyte disturbances that trigger TdP.
The most up-to-date information is available on www.crediblemeds.org. A free mobile app is also available for iPhone and Android.
References
CredibleMeds QT drugs list website, sponsored by the Science Foundation of the University of Arizona. Available at: https://crediblemeds.org/