ARC HBR definition

Major HBR criteria

Anticipated long-term oral anticoagulation

Severe/End-stage CKD (eGFR <30 ml/min)

Hb <11 g/dl

Spontaneous bleeding requiring hospitalization or transfusion in the past 6 mo or any time, if recurrent

Moderate/severe basline thrombocytopenia (<100x 10⁹/L)

100,000 /μL = 100 x 10⁹ /L

Chronic bleeding diathesis

Liver cirrhosis with portal hypertension

Active malignancy (excluding nonmelanoma skin cancer) within the past 12 months

Previous spontaneous ICH (at any time)/traumatic ICH (within the past 12 months)/ presence of a bAVM/ moderate or severe ischemic stroke within the past 6 mo

Nondeferrable major surgery on DAPT

Recent major surgery or major trauma within 30 day before PCI

Minor HBR criteria

Age ≥75 y

Moderate CKD (eGFR 30-59 ml/min)

Hb 11-12.9 g/dl for men and 11-11.9 g/dl for women

Spontaneous bleeding requiring hospitalization or transfusion within the past 12 mo not meeting the major criterion

Long-term use of oral NSAIDs or steroids

Any ischemic stroke at any time not meeting the major criterion

According to the ARC HBR definition, patients are considered to be at HBR if at least 1 major or more than 2 minor criteria are met

Result

-

Reference

Philip Urban, Roxana Mehran, Roisin Colleran, Dominick J Angiolillo, Robert A Byrne, Davide Capodanno, Thomas Cuisset, Donald Cutlip, Pedro Eerdmans, John Eikelboom, Andrew Farb, C Michael Gibson, John Gregson, Michael Haude, Stefan K James, Hyo-Soo Kim, Takeshi Kimura, Akihide Konishi, John Laschinger, Martin B Leon, P F Adrian Magee, Yoshiaki Mitsutake, Darren Mylotte, Stuart Pocock, Matthew J Price, Sunil V Rao, Ernest Spitzer, Norman Stockbridge, Marco Valgimigli, Olivier Varenne, Ute Windhoevel, Robert W Yeh, Mitchell W Krucoff, Marie-Claude Morice, Defining high bleeding risk in patients undergoing percutaneous coronary intervention: a consensus document from the Academic Research Consortium for High Bleeding Risk, European Heart Journal, Volume 40, Issue 31, 14 August 2019, Pages 2632–2653, https://doi.org/10.1093/eurheartj/ehz372