Sulbactam for A. baumannii
Normal Dose
(Full dose)
Sulbactam:
Susceptible: 3-4 g/day
Intermediate resistant 6-8 g/day
Resistant : 9-12 g/day
CrCl
(ml/min)
>30
15-29
<15
Intermittent HD
CRRT
CAPD
Sulperozone
or
Unasyn
3 g q 24 h
1 g q 12 h
3 g q 24 h
2 g q 12 h
3 g q 12 h
2 g q 8 h
3 g q 8 h
3 g q 12 h
3 g q 24 h
Conditions | Dose |
|---|---|
CrCl > 30 ml/min | Sulperazone 2 g iv q8h or Unasyn 3 g q8h |
CrCl 15-29 ml/min | Sulperazone 2 g iv q12h or Unasyn 3 g q12h |
CrCl <15 ml/min | Sulperazone 1 g iv q12h or Unasyn 3 g q24h |
Hemodialysis | Unasyn 3 g q24h |
CAPD | Unasyn 3 g q24h |
CRRT | Unasyn 3 g q12h |
SLED | Unasyn 3 g q12h |
Conditions | Dose |
|---|---|
CrCl > 30 ml/min | Sulperazone 4 g q8h + vit K1 10 mg/wk or Unasyn 3 g q4h |
CrCl 15-29 ml/min | Sulperazone 3 g iv q12h or Unasyn 3 g q8h |
CrCl <15 ml/min | Sulperazone 2 g iv q12h or Unasyn 3 g q12h |
Cefoperazone doses exceeding 4.5 g/day increase the risk of hypoprothrombinemia to 4.5-12.3%. Therefore, Vitamin K1 10 mg/week should be prescribed.
Conditions | Dose |
|---|---|
CrCl > 30 ml/min | Sulperazone 4 g q8h + vit K1 10 mg/wk AND Unasyn 3 g q6h |
CrCl 15-29 ml/min | Sulperazone 3 g iv q8h + vit K1 10 mg/wk AND Unasyn 3 g q6h |
CrCl <15 ml/min | Sulperazone 3 g iv q12h AND Unasyn 3 g q8h |
Cefoperazone doses exceeding 4.5 g/day increase the risk of hypoprothrombinemia to 4.5-12.3%. Therefore, Vitamin K1 10 mg/week should be prescribed.
The Cockcroft-Gault equation may yield inaccurate estimates based on a patient's body weight and BMI. By including additional height information, we can calculate BMI and provide a modified estimate and range.
- Underweight: For a BMI of 18.5 or less, use the actual body weight for calculations.
- Normal Weight: Use the ideal body weight for calculations.
- Overweight/Obese: For a BMI of 25 or higher, use the adjusted body weight for calculations.
Calculation Steps
-
.