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Piperacillin 4 gm/Tazobactam 0.5 gm
Normal Dose
(Full dose)
4.5 gm q 6 h (over 30 min)
30 min infusion
CrCl
(ml/min)
>40-90
20-40
10-20
Intermittent HD
CRRT
CAPD
Piperacillin 4 gm / Tazobactam 0.5 gm
2.25 gm q 8 h
(+ 0.75 gm after dialysis)
2.25 gm q 6 h
3.375 gm q 6 h
4.5 gm q 6 h
MIC </=16 3.375 gm
(over 30 min) q 6 h
MIC > 16 to 64: 4.5 gm (over 4 h) q 8 h
2.25 g q 8 h
<10
2.25 gm q 6 h
In selected cases: Higher piperacillin/tazobactam dosing may be warranted, e.g., sepsis, critically ill, patients with severe infection, infection with MIC > 16 mg/L, obesity with weight > 120 kg or BMI> 40, CrCl > 120, consider extended infusion dosing. (infuse over 4 h)
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