Imipenem (0.5 gm/vial)

Normal Dose
(Full dose)

500 mg q 6 h

CrCl
(ml/min)

>50-90

10 - 50

<10

Intermittent HD

CRRT

CAPD

Imipenem
0.5 gm/Vial

125-250 mg q 12 h
(give one of the dialysis day dose after dialysis)

125-250 mg q 12h

250-500 mg q 8-12h

500 mg V q 6-8 h

0.5 - 1 gm q 12 h

125-250 mg q 12 h

Line selected

Conditions	Dose
CrCl > 60 ml/min	500 mg IV q6H or 1g IV q8h
CrCl 30-59 ml/min	500 mg IV q8h
CrCl 15-29 ml/min	500 mg IV q12h
CrCl <15 ml/min	Not recommended unless dialysis initiated within 48-hrs
Hemodialysis	250 - 500 mg IV q12h
CAPD	No data
CRRT	1g load, then 500 mg IV q6h
SLED	No data

Conditions	Dose
CrCl > 60 ml/min	1000 mg IV q12h
CrCl 30-59 ml/min	750 mg IV q12h
CrCl 15-29 ml/min	500 mg IV q12h
CrCl <15 ml/min	Not recommended unless dialysis initiated within 48-hrs
Hemodialysis	250 - 500 mg IV q12h
CAPD	No data
CRRT	1g load, then 500 mg IV q6h
SLED	No data

The Cockcroft-Gault equation may yield inaccurate estimates based on a patient's body weight and BMI. By including additional height information, we can calculate BMI and provide a modified estimate and range.

- Underweight: For a BMI of 18.5 or less, use the actual body weight for calculations.

- Normal Weight: Use the ideal body weight for calculations.

- Overweight/Obese: For a BMI of 25 or higher, use the adjusted body weight for calculations.

Calculation Steps

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