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Ceftazidime/Avibactam
Normal Dose
(Full dose)
2.5 g q 8 h
CrCl
(ml/min)
>51
31-50
16-30
Intermittent HD
CRRT
Ceftazidime/
Avibactam
750 mg/187.5 mg
q 12 h
1 g/0.25 g q 8 h
2.5 g IV q 8 h
in 2 h
6-15
750 mg/187.5 mg
q 24 h
<6
750 mg/187.5 mg
q 48 h
750 mg/187.5 mg
q 48 h (after dialysis on HD day)
1 g/0.25 g q 8 h
(2.5 g q 8 h
if MIC>4 mcg/ml)
CAPD
Conditions | Dose |
|---|---|
CrCl > 50 ml/min | 2.5 g IV q8h |
CrCl 30 - 50 ml/min | 1 / 0.25 g IV q8h |
CrCl 16 - 30 ml/min | 750 / 187.5 mg IV q12h |
CrCl 6 - 15 ml/min | 750 / 187.5 mg IV q24h |
CrCl < 6 ml/min | 750 / 187.5 mg IV q48h |
Hemodialysis | 750 / 187.5 mg IV q8h |
Dose daily, but after HD on HD days | |
CAPD | No data |
CRRT | 1 / 0.25 g q8h |
(2.5 g q8h if MIC>4 mcg/ml) | |
SLED | No data |
The Cockcroft-Gault equation may yield inaccurate estimates based on a patient's body weight and BMI. By including additional height information, we can calculate BMI and provide a modified estimate and range.
- Underweight: For a BMI of 18.5 or less, use the actual body weight for calculations.
- Normal Weight: Use the ideal body weight for calculations.
- Overweight/Obese: For a BMI of 25 or higher, use the adjusted body weight for calculations.
Calculation Steps
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