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Cefepime
Normal Dose
(Full dose)
1-2 gm q 8 h
Extend infusion: 4 h infusion
CrCl
(ml/min)
>60
30-60
11-29
Intermittent HD
CRRT
CAPD
Cefepime
0.5-1 g q 24 h
dose daily but after dialysis on dialysis day
1 g q 24 h
1 g q 12 h or
2 g q 24 h
1 g q 8 h or
2 g q 12 h
2 g load then
1 g q 8 h
<10
500 mg q 24 h
Conditions | Dose |
|---|---|
CrCl > 60 ml/min | 1 g IV Q8H or 2 g IV Q12H, 4-hour infusion |
CrCl 30-60 ml/min | 1 g IV Q12H or 2 g IV Q24H, 4-hour infusion |
CrCl 11-29 ml/min | 1 g IV Q24H, 4-hour infusion |
CrCl < 10 ml/min | 500 mg IV Q24H, 4-hour infusion |
Hemodialysis | 0.5 - 1 g IV Q24H Dose daily |
but after HD on HD days | |
CAPD | 2 g IV Q48H |
CRRT | 2 g IV load, then 1 g IV Q8H (over 4 h) |
SLED | 2 g load, then 1 gm Q6H |
2 g pre-, 3 g post-SLED |
Conditions | Dose |
|---|---|
CrCl > 60 ml/min | 2 g IV Q8H, 4-hour infusion |
CrCl 30-60 ml/min | 2 g IV Q12H, 4-hour infusion |
CrCl 11-29 ml/min | 1 g IV Q12H, 4-hour infusion |
CrCl < 10 ml/min | 1 g IV Q24H, 4-hour infusion |
Hemodialysis | 0.5 - 1 g IV Q24H Dose daily |
but after HD on HD days | |
CAPD | 2 g IV Q48H |
CRRT | 2 g IV load, then 1 g IV Q8H (over 4 h) |
SLED | 2 g load, then 1 gm Q6H |
2 g pre-, 3 g post-SLED |
The Cockcroft-Gault equation may yield inaccurate estimates based on a patient's body weight and BMI. By including additional height information, we can calculate BMI and provide a modified estimate and range.
- Underweight: For a BMI of 18.5 or lesser, use the actual body weight for calculations.
- Normal Weight: Use the ideal body weight for calculations.
- Overweight/Obese: For a BMI of 25 or higher, use the adjusted body weight for calculations.
Calculation Steps
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