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Midazolam

Max concentration : Undiluted (5 mg/ml)

Solution: NSS, D5W

Dosing instruction: Bolus Dose 0.03-0.3 mg/kg (0.5-4 mg)

                                  Infusion rate: 0.02-0.2 mg/kg/min

                                  Titrate dose by 1 mg/h to achieve desired effect

Body Weight 

kg.

Midazolam 20mg/100ml (0.2 mg/ml)

Rate (ml/hr) 

6ml/h

Midazolam 50mg/100ml (0.5 mg/ml)

Rate (ml/hr) 

2ml/h

Dose (mg/kg/h) 

Richmond Agitation-Sedation Scale (RASS)

RASS score 

RASS scoring and interpretation should be based on the sedation protocol being used. For minimal sedation protocols (RASS -2 to 0), sedation should be modified or decreased for a RASS score of -3 or less.

+4     Combative, violent, danger to staff

+3     Pulls or removes tube(s) or catheters; aggressive

+2     Frequent non-purposeful movement, fights ventilator

+1     Anxious, apprehensive, but not aggressive

  0     Alert and calm

-1      Awakens to voice (eye opening/contact) > 10 seconds

-2      Light sedation; briefly awakens to voice (eye opening/contant) < 10 seconds

-3      Moderate sedation; movement or eye opening. No eye contact

-4      Deep sedation; no response to voice, but movement or eye opening to physical stimulation

-5      Unarousable; no response to voice or physical stimulation

Voice

©2023 BY Piti Niyomsirivanich, MD. (Personal use)
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