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Dobutamine

Stereoisomers

Two molecular structures are shown:

  • (+) stereoisomer (blue structure)

  • (–) stereoisomer (red structure)

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These represent the two enantiomers (mirror-image stereoisomers) of Dobutamine.

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(+) stereoisomer

  • Alpha-1: High affinity, acts as a competitive alpha-antagonist

  • Beta-1: Potent full agonist

  • Beta-2: Low potency full agonist

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(-) stereo isomer

  • Alpha-1: High affinity and potent partial agonist

  • Beta-1: Full agonist with very low potency

  • Beta-2: Minimal effect​

Pharmacokinetic

Absorption: When administered intravenously, dobutamine begins to take effect in 1 to 2 minutes. However, the maximum effect of an infusion may take up to 10 minutes to be reached.

Distribution: The plasma half-life of dobutamine is approximately 2 minutes.

Metabolism: Dobutamine is primarily metabolized through catechol methylation and conjugation.

Excretion: The main byproducts excreted in human urine are the conjugates of dobutamine and 3-O-methyl dobutamine.

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